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提示：本页所有资料为英文资料。
美国专利目录:
PAT. NO. Title
1 6,719,975 Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin
2 6,514,730 Secretion of hirudin derivatives
3 6,060,451 Thrombin inhibitors based on the amino acid sequence of hirudin
4 6,028,170 Analogs of hirudin
5 5,972,648 Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients
6 5,919,895 Secretion of hirudin derivatives
7 5,919,762 Conjugates of hirudin and lipophilic compounds
8 5,902,735 Functional DNA block and plasmid coding for hirudin, transformed yeast, method for hirudin, hirudin obtained, and its pharmaceutical use
9 5,880,258 Anticoagulant hirudin variants and methods for their production
10 5,879,926 Yeast strains for the production of mature heterologous proteins, especially hirudin
11 5,866,399 Process for inactivating carboxypeptidase Y in hirudin-containing culture broths
12 5,837,808 Analogs of hirudin
13 5,824,505 Vectors, transformed cells and process for the preparation of hirudin
14 5,821,079 Vectors for the expression and secretion of hirudin by transformed yeasts
15 5,817,309 Antidote for hirudin and synthetic thrombin inhibitors and method of use
16 5,767,235 Anticoagulant hirudin variants and methods for their production
17 5,705,355 Hirudin, pharmaceutical compositions comprising it and their use
18 5,698,104 Purification process for hirudin using affinity chromatography
19 5,686,564 Peptide derivatives corresponding to the carboxy terminal sequence of hirudin
20 5,674,838 Hirudin derivatives and a process for their preparation
21 5,663,141 Hirudin/polyalkylene glycol conjugates and hirudin muteins
22 5,650,301 Hirudin HV2 having a SN7LYS substitution, method of making, and method of use
23 5,624,822 Hirudin fusion proteins and preparation of hirudin
24 5,591,640 Functional DNA block and plasmid coding for hirudin, transformed yeast, method for preparing hirudin, hirudin obtained and its pharmaceutical use
25 5,574,012 Analogs of hirudin having anti-platelet activity
26 5,573,929 Secretion vector for hirudin or hirudin analog production
27 5,547,850 Process for determining hirudin and synthetic thrombin inhibitors
28 5,541,161 Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
29 5,538,946 Hirudin derivatives with delayed action
30 5,516,656 Production of a new hirudin analog and anticoagulant pharmaceutical composition containing the same
31 5,472,938 Pharmaceutical depot compositions containing hirudin
32 5,362,858 Polyethylene glycol-hirudin conjugates, process for preparing them and their use for the treatment of thromboses
33 5,304,310 Method for concentrating and purifying hirudin from leeches
34 5,296,352 Monoclonal antibodies directed against complexes formed by thrombin and hirudin
35 5,272,059 Monoclonal antibodies specific for hirudin
36 5,204,323 Heparin and hirudin antidotal compositions and methods
37 5,180,668 Hirudin derivative
38 5,167,960 Hirudin-coated biocompatible substance
39 5,164,304 Method and vectors for stabilizing hirudin and human laminin B.sub.1 expression
40 5,118,790 Analogs of hirudin
41 5,112,615 Soluble hirudin conjugates
42 5,095,092 Process for the isolation and purification of hirudin
43 5,087,613 Hirudin variants
44 4,767,742 Hirudin-PA and its derivatives, process for manufacturing these and the use of these substances
PUB. APP. NO. Title
1 20050095685 Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin
2 20040228852 Use of increased molecular-weight hirudin as an anticoagulant in extracorporeal kidney replace therapy
3 20030176673 Nucleic acids, proteins, and processes thereof such as use of fusion proteins whose N-terminal part is a hirudin derivative for the production of recombinant proteins via secretion by yeasts
4 20020173620 Bifunctional fusion proteins formed from hirudin and TAP
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